Apl. Prof. Dr. Erik Schleicher

Adjunct professor                                   

Lectures

• Vorlesung  "Physikalische Chemie für Studierende der Biologie, und Molekularen Medizin" (PC-BMM)

• Vorlesung  "Moderne spektroskopische Methoden der Biophysik" (PC V) (in English)

Scientific responseman of the computer pool (CIP-pool chemistry /Albertstraße 21)

If you have questions regarding the CIP-Pool please contact: cip-support@cl.uni-freiburg.de

Scientific Expertise

• EPR of (light active) proteins and enzymes
• Flavoproteins
• Protein chemistry and molecular biology
• Spinmarkierung
• time-resolved optical spectroscopy

Wissenschaftliche Interessen

• DNA Photolyasen (CPD Photolyasen und (6-4) Photolyasen)
• Blaulicht-Photorezeptoren (Phototropine, Cryptochrome und BLUF-Domänen)
• andere biologisch-relevante Flavoproteine
• Eisen-Schwefel- und andere Übergangsmetall Cluster

List of publications

Researcher-ID: C-9951-2010

Flavins und Flavoproteins: Methods and Protocols. Weber S, Schleicher E (Eds.) Series: Methods in Molecular Biology, Vol. 1146, Humana Press 2014 Weiterlesen...

Fünf ausgewählte Publikationen:

• Biskup T, Paulus A, Okafuji A, Hitomi K, Getzoff ED, Weber S, Schleicher E (2013) Variable electron transfer pathways in an amphibian cryptochrome. Tryptophan versus tyrosine-based radical pairs. J Biol Chem 288:9249–9260.
• Brosi R, Illarionov B, Mathes T, Fischer M, Joshi M, Bacher A, Hegemann P, Bittl R, Weber S, Schleicher E (2010) Hindered rotation of a cofactor methyl group as a probe for protein– cofactor interaction. J Am Chem Soc 132:8935-8944.
• Henbest KB, Maeda K, Hore PJ, Joshi M, Bacher A, Bittl R, Weber S, Timmel CR, Schleicher E (2008) Magnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase. Proc Natl Acad Sci USA 105:14395-14399.
• Banerjee R, Schleicher E, Meier S, Viana RM, Pokorny R, Ahmad M, Bittl R, Batschauer A, (2007) The signaling state of Arabidopsis cryptochrome 2 contains flavin semiquinone. J Biol Chem 282:14916-14922.
• Bouly JP, Schleicher E, Dionisio-Sese M, Vandenbussche F, Van der Straeten D, Bakrim N, Meier S, Batschauer A, Galland P, Bittl R, Ahmad M (2007) Cryptochrome blue-light photoreceptors are activated through interconversion of flavin redox states. J Biol Chem 282: 9383-9391.

Buchartikel / Konferenz-Sonderbände:

• B. Paulus,C. Bajzath, S. Weber, E. Schleicher: "Flavoproteins and blue light reception in plants" in "Handbook of Flavoproteins. Volume 2: Complex Flavoproteins, Dehydrogenases and Physical Methods", R. Hille, S. Miller, B. Palfey (Editors) Walter de Gruyter (2013)
• T. Biskup, J.R. Norris, A. Okafuji, A.R. Marino, K. Hitomi, E.D. Getzoff, E. Schleicher, S. Weber: "Characterization of light-induced spin-correlated radical pairs in cryptochromes – Basis for a magnetic compass?" in "Flavins and Flavoproteins 2011", S. Miller, R. Hille, B. Palfey (Editors), Lulu.com (2013), Raleigh, NC, pp. 385–396
• E. Schleicher, S. Weber: "Radicals in flavoproteins". Topic in Current Chemistry, 2012; 321: 41-66
• C.W.M. Kay, A. Bacher, M. Fischer, G. Richter, E. Schleicher, S. Weber: "Chapter 8: Blue light-induced DNA repair by photolyase" in "Flavins. Photochemistry and Photobiology", E. Silva, A.M. Edwards (Editors), Volume 6 of "Comprehensive Series in Photochemical and Photobiological Sciences", D.P. Häder, G. Jori (Series Editors), RSC Publishing (2006), Cambridge, UK, pp. 151–182
• S. Hecht, G. Richter, A. Bacher, M. Joshi, W. Römisch, G. Greiner, R. Frank, S. Weber, W. Eisenreich, M. Fischer:" Photocycle of a blue light receptor LOV2 domain reconstituted with 5-deaza-FMN" in "Flavins and Flavoproteins 2005", T. Nishino, R. Miura, M. Tanokura, K. Fukui (Editors), ARchiTect Inc., Tokyo (2005), pp. 569–574
• G. Richter, A. Bacher, S. Weber, W. Römisch, M. Joshi, M. Fischer, W. Eisenreich: "Studies of the photocycle of the blue-light receptor phototropin. Observation of nuclear-spin polarization by solution ¹³C-NMR" in "Flavins and Flavoproteins 2005", T. Nishino, R. Miura, M. Tanokura, K. Fukui (Editors), ARchiTect Inc., Tokyo (2005), pp. 587–591
• C.W.M. Kay, E. Schleicher, R. Bittl, A. Bacher, G. Richter, K. Hitomi, T. Ishikawa, T. Todo, S. Weber: "The g-tensor of neutral flavin radicals" in "Flavins and Flavoproteins 2005", T. Nishino, R. Miura, M. Tanokura, K. Fukui (Editors), ARchiTect Inc., Tokyo (2005), pp. 601–606
• E. Schleicher, B. Heßling, V. Illarionova, A. Bacher, S. Weber, K. Gerwert, G. Richter: "A vibrational spectroscopic study of light-induced protein structural changes in Escherichia coli DNA photolyase" in "Flavins and Flavoproteins 2005", T. Nishino, R. Miura, M. Tanokura, K. Fukui (Editors), ARchiTect Inc., Tokyo (2005), pp. 617–622
• E. Schleicher, R.M. Kowalczyk, C.W.M. Kay, G. Richter, A. Bacher, R. Bittl, S. Weber: "Direct EPR-observation of the photo-induced triplet state of flavin mononucleotide" in "Flavins and Flavoproteins 2005", T. Nishino, R. Miura, M. Tanokura, K. Fukui (Editors), ARchiTect Inc., Tokyo (2005), pp. 623–628
• C.W.M. Kay, A. Kuppig, E. Schleicher, A. Bacher, G. Richter, S. Weber: "Photochemistry of a C450A mutant of the LOV2 domain in phototropin: detection of a light-induced neutral flavin radical by EPR spectroscopy" in "Flavins and Flavoproteins 2002" (S. Chapman, R. Perham, N. Scrutton, Editors), Rudolf Weber Agency for Scientific Publishing, Berlin (2002) 707–712
• C.W.M. Kay, H. Mögling, E. Schleicher, K. Hitomi, K. Möbius, T. Todo, A. Bacher, G. Richter, S. Weber: "A comparative time-resolved electron paramagnetic resonance study of the flavin cofactor photoreduction in Escherichia coli cyclobutane pyrimidine dimer photolyase and Xenopus laevis (6–4) photolyase" in "Flavins and Flavoproteins 2002" (S. Chapman, R. Perham, N. Scrutton, Editors), Rudolf Weber Agency for Scientific Publishing, Berlin (2002) 713–718
• G. Richter, W. Römisch, E. Schleicher, M. Fischer, A. Bacher, W. Eisenreich, M. Salomon, E. Knieb, H. Dürr, W. Rüdiger, V. Massey, F. Müller, S. Weber: "NMR studies on the mechanism of the blue light receptor phototropin from Avena sativa" in "Flavins and Flavoproteins 2002" (S. Chapman, R. Perham, N. Scrutton, Editors), Rudolf Weber Agency for Scientific Publishing, Berlin (2002) 719–724

CV

besondere wissenschaftliche Aktivitäten

DFG-Projekt: "Light-induced magnetization detected by force microscopy: from basic concept to first applications."
SPP 1601: New frontiers in sensitivity for EPR spectroscopy: from biological cells to nano materials. 2012 bis 2015.

Herausgeberschaft des Buches "Methods in Molecular Biology" über Flavine und Flavoproteine für Humana Press/USA mit Stefan Weber in Zusammenhang mit dem Springer Verlag, 2011 bis 2013.

Habilitationsvortrag am 19.7.2011 an der Universität Freiburg über "Der molekulare Mechanismus von Blaulicht-Photorezeptoren", 2011.

Eugen-Graetz-Preis der Albert-Ludwigs-Universität "Untersuchungen des magnetischen Kompasses von Zugvögeln", Institut für Physikalische Chemie I, Universität Freiburg, 2009.